検索結果

Search Results for " OX Receptor "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T4965	TCS-OX2-29		OX Receptor
	TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.		OX Receptor
T5503	IPSU		OX Receptor
	IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.		OX Receptor
T11186	EMPA		OX Receptor
	EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively)		OX Receptor
T3177	Orexin 2 Receptor Agonist	OX2R	OX Receptor
	Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.		OX Receptor
T1913	MK-3697		OX Receptor
	MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).		OX Receptor
T16096	Filorexant	MK-6096	OX Receptor
	Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).		OX Receptor
T5498	SB-649868	GSK649868	OX Receptor
	SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).		OX Receptor
T12877L	Seltorexant	JNJ-42847922	OX Receptor
	Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a...		OX Receptor
T2710	TCS 1102		OX Receptor
	TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).		OX Receptor
T3722	MK-1064	Urokinase inhibitor 1,MK 1064	OX Receptor
	MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).		OX Receptor
T6658	SB-408124		OX Receptor
	SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.		OX Receptor
T2613	Almorexant	ACT 078573	OX Receptor
	Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.		OX Receptor
T6140	SB-334867 free base	SB334867A free base,SB-334867,SB 334867,SB334867	OX Receptor
	SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.		OX Receptor
T6155	Almorexant hydrochloride	ACT-078573 hydrochloride,Almorexant HCl	OX Receptor
	Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.		OX Receptor
T37112	YNT-185 dihydrochloride
	Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depo...
T77181	Revdofilimab
	Revdofilimab (ABBV-368) is a human IgG1 monoclonal antibody that functions as an agonist against OX40, a member of the TNF receptor superfamily. OX40 is expressed on activated and memory T cell subsets as well as T regul...
T35463	(±)14(15)-EET	(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) i...

Compounds

TCS-OX2-29

T4965

Synonym:

Target: OX Receptor

IPSU

T5503

Synonym:

Target: OX Receptor

EMPA

T11186

Synonym:

Target: OX Receptor

Orexin 2 Receptor Agonist

T3177

Synonym: OX2R

Target: OX Receptor

MK-3697

T1913

Synonym:

Target: OX Receptor

Filorexant

T16096

Synonym: MK-6096

Target: OX Receptor

SB-649868

T5498

Synonym: GSK649868

Target: OX Receptor

Seltorexant

T12877L

Synonym: JNJ-42847922

Target: OX Receptor

TCS 1102

T2710

Synonym:

Target: OX Receptor

MK-1064

T3722

Synonym: Urokinase inhibitor 1,MK 1064

Target: OX Receptor

SB-408124

T6658

Synonym:

Target: OX Receptor

Almorexant

T2613

Synonym: ACT 078573

Target: OX Receptor

SB-334867 free base

T6140

Synonym: SB334867A free base,SB-334867,SB 334867,SB334867

Target: OX Receptor

Almorexant hydrochloride

T6155

Synonym: ACT-078573 hydrochloride,Almorexant HCl

Target: OX Receptor

YNT-185 dihydrochloride

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Target:

カタログ番号	製品名	別名	ターゲット
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite

天然物製品

Isorhamnetin

T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01423	OX40/TNFRSF4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	OX40/TNFRSF4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is P43489.
TMPJ-01458	OX40/TNFRSF4 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	OX40/TNFRSF4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-50 KDa and the accession number is XM_005545122.1.
TMPJ-00422	OX40/TNFRSF4 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	OX40/TNFRSF4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40 KDa and the accession number is P47741.
TMPK-01168	LOX-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion...
TMPK-00464	OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; i...
TMPY-06875	OX40/TNFRSF4 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	OX40/TNFRSF4 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 48.69 kDa and the accession number is NP_003318.1.
TMPY-05339	OX40/TNFRSF4 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	OX40/TNFRSF4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.9 kDa and the accession number is P43489.
TMPY-06906	OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.34 kDa and the accession number is NP_003318.1.
TMPK-00167	OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; i...
TMPK-00463	OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; i...
TMPK-00168	OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; i...
TMPK-00169	OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; i...
TMPJ-00233	CD200R1/CRTR2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain ...